Elmér O, Göransson G, Zoucas E, Bengmark S
Res Exp Med (Berl). 1983;182(1):13-9. doi: 10.1007/BF01852282.
Alcohol ingestion results in the formation of circulating microaggregates in the pig. To investigate the underlying mechanism, the effects of alcohol on platelet aggregation using a Born-aggregometer, was investigated. After incubating unstirred platelet rich plasma (PRP) with moderate concentrations of alcohol (175 mmol/l) the aggregation induced by collagen was reduced. This was probably due to platelet refractoriness caused by platelet ADP release. We could also demonstrate that high concentrations of alcohol (630 mmol/l) caused platelet release in stirred PRP. Release of ADP from red cells, after incubating unstirred whole blood with low concentrations of alcohol (17 mmol/l), was the probable explanation to the observed platelet refractoriness to ADP and collagen. Alcohol causing release of ADP from red cells is likely the cause of platelet aggregation in circulating blood and is probably the mechanism in formation of circulating platelet aggregates after alcohol ingestion.
酒精摄入会导致猪体内形成循环微聚体。为了探究其潜在机制，研究了酒精对使用玻恩血小板聚集仪检测的血小板聚集的影响。用中等浓度的酒精（175 mmol/l）孵育未搅拌的富血小板血浆（PRP）后，胶原诱导的聚集减少。这可能是由于血小板释放ADP导致血小板不应性所致。我们还能证明，高浓度酒精（630 mmol/l）会导致搅拌的PRP中血小板释放。用低浓度酒精（17 mmol/l）孵育未搅拌的全血后，红细胞释放ADP可能是观察到的血小板对ADP和胶原不应性的原因。酒精导致红细胞释放ADP可能是循环血液中血小板聚集的原因，也可能是酒精摄入后循环血小板聚集体形成的机制。
