Arsène D, Verwaerde J C, Rideau A, Sassier J C, Valla A, Thomas M
Rev Fr Transfus Immunohematol. 1983 Feb;26(1):45-65. doi: 10.1016/s0338-4535(83)80049-x.
175 Chronic HBs Ag carriers have been discovered in the blood donors of the Calvados blood transfusion center from 1971 to 1979. 72 of them (41%) gave their consent for a clinical and biological study at the end of 1979, after receiving a convocation letter. This work had two aims: - to study the epidemiological factors in this population. - to evaluate the clinical and biological consequences of persistent antigenemia. 1. Epidemiological Study. Most results agree with the literature (higher prevalence in male, age, stay in endemic countries) but some results disagree for several reasons: our donors are all volunteers, HBs Ag prevalence is low in our region, most of the patients are caucasian and with life conditions and habits which may explain some particularities in contagion. Furthermore, the relative number of blood donors found every year as chronic HBs Ag carriers, does not increase in our country. 2. The Clinical and Biological follow-up of 62 HBs Ag carriers (alcoholics excluded) was carried out for 4,3 years on average. No patients developed clinical and biological features of chronic liver disease. After a mean term follow-up, we conclude that the asymptomatic HBs Ag carriers state seems not to be of bad prognostic. Since long term complications cannot be excluded, the follow-up of these patients must be maintained.
1971年至1979年期间，在卡尔瓦多斯输血中心的献血者中发现了175名慢性乙肝表面抗原携带者。1979年底，其中72人（41%）在收到召集信后同意接受临床和生物学研究。这项工作有两个目的：- 研究该人群中的流行病学因素。- 评估持续性抗原血症的临床和生物学后果。1. 流行病学研究。大多数结果与文献一致（男性、年龄、在流行国家居住的患病率较高），但有些结果因多种原因不一致：我们的献血者都是志愿者，我们所在地区乙肝表面抗原患病率较低，大多数患者是白种人，其生活条件和习惯可能解释了传染方面的一些特殊性。此外，我国每年发现的作为慢性乙肝表面抗原携带者的献血者相对数量并未增加。2. 对62名乙肝表面抗原携带者（不包括酗酒者）平均进行了4.3年的临床和生物学随访。没有患者出现慢性肝病的临床和生物学特征。经过平均随访期后，我们得出结论，无症状乙肝表面抗原携带者状态似乎预后并不差。由于不能排除长期并发症，必须对这些患者进行持续随访。
