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秀丽隐杆线虫中神经元分支的诱导

Induction of neuronal branching in Caenorhabditis elegans.

作者信息

Chalfie M, Thomson J N, Sulston J E

出版信息

Science. 1983 Jul 1;221(4605):61-3. doi: 10.1126/science.6857263.

Abstract

The two postembryonic touch receptor neurons in the nematode Caenorhabditis elegans arise from essentially identical cell lineages and have the same ultrastructural features. The cells are found in different positions in the animal, however, and differ in neuronal branching, connectivity, and function. These structural and functional differences are not seen when cells are placed in similar positions by mutation or laser-induced damage. Thus, some, but probably not all, of the differentiated properties of these cells are a consequence of their cellular environment.

摘要

线虫秀丽隐杆线虫中的两个胚后触觉受体神经元起源于基本相同的细胞谱系,并且具有相同的超微结构特征。然而,这些细胞在动物体内处于不同位置,在神经元分支、连接性和功能方面存在差异。当通过突变或激光诱导损伤将细胞置于相似位置时,并未观察到这些结构和功能差异。因此,这些细胞的一些(但可能不是全部)分化特性是其细胞环境的结果。

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