Mosekilde L, Melsen F
Acta Med Scand. 1978;204(1-2):97-102. doi: 10.1111/j.0954-6820.1978.tb08406.x.
Increased bone, resorption previously found in hyperthyroidism might be caused by a direct stimulating effect of thyroid hormone(s) on bone cells or by an increased sensitivity to circulating parathyroid hormone. In order to disclose qualitative differences in the response of bone resorbing cells to excess parathyroid hormone and excess thyroid hormone(s), histomorphometric analysis of iliac crest biopsies was performed in 25 hyperparathyroid and 40 hyperthyroid patients after tetracycline double-labelling. The main target cells for parathyroid and thyroid hormones were different. Parathyroid hormone stimulated osteocytic osteolysis and increased osteoclastic resorption surfaces equally in trabecular and cortical bone. The osteoclastic resorption was inactive. Thyroid hormone(s) had no effect on osteocytes but increased the osteoclastic resorption surfaces in trabecular and cortical bone, with a pronounced preponderance in cortical bone. The osteoclastic resorption was active and followed by a significant loss of both cortical and trabecular bone. The findings support the assumption that increased bone resorption in hyperthyroidism is caused by a direct stimulating effect of thyroid hormone(s).
先前在甲状腺功能亢进症中发现的骨吸收增加，可能是由于甲状腺激素对骨细胞的直接刺激作用，或者是由于对循环甲状旁腺激素的敏感性增加所致。为了揭示骨吸收细胞对甲状旁腺激素过量和甲状腺激素过量反应的质性差异，对25例甲状旁腺功能亢进患者和40例甲状腺功能亢进患者进行四环素双重标记后，对髂嵴活检进行了组织形态计量分析。甲状旁腺激素和甲状腺激素的主要靶细胞不同。甲状旁腺激素刺激骨细胞性骨溶解，并同等程度地增加小梁骨和皮质骨中的破骨细胞吸收表面。破骨细胞吸收不活跃。甲状腺激素对骨细胞没有影响，但增加了小梁骨和皮质骨中的破骨细胞吸收表面，在皮质骨中尤为明显。破骨细胞吸收活跃，随后皮质骨和小梁骨均出现明显丢失。这些发现支持了甲状腺功能亢进症中骨吸收增加是由甲状腺激素的直接刺激作用引起的这一假设。
