Melsen F, Mosekilde L
Acta Pathol Microbiol Scand A. 1977 Mar;85A(2):141-50. doi: 10.1089/ten.2005.11.1034.
Bone biopsies were performed after tetracycline double-labelling by transfixing the right iliac crest in forty hyperthyroid patients. The bone changes in cortical and trabecular bone were determined by simple measurement and point counting on decalcified and undecalcified stained sections. A slight decrease in the amount of cancellous bone was found. The mean cortical width was normal. The amount of osteoid and the length of the osteoid seams were increased, whereas the mean width of osteoid seams was decreased. The cortical osteoclastic activity and porosity were markedly increased. The trabecular osteoclasic activity was moderately increased and the mean size of periosteocytic lacunae was slightly increased. The calcification rate in cancellous bone was increased as were the active calcification surfaces (tetracycline-labelled). The osteoclastic activity in cortical bone was positively correlated to the free thyroxine index and to the urinary calcium and phosphorus excretion. The findings indicate that the bone changes in hyperthyroidism are specific and that thyroid hormone(s) stimulates both bone formation and resorption followed by increased porosity in cortical bone and by mobilization of bone mineral.
对40例甲状腺功能亢进患者，经四环素双重标记后，通过穿刺右髂嵴进行骨活检。通过对脱钙和未脱钙染色切片进行简单测量和点计数，确定皮质骨和小梁骨的骨变化。发现松质骨量略有减少。平均皮质宽度正常。类骨质的量和类骨质缝的长度增加，而类骨质缝的平均宽度减小。皮质骨破骨细胞活性和孔隙率明显增加。小梁骨破骨细胞活性中度增加，骨膜细胞陷窝的平均大小略有增加。松质骨的钙化率增加，活性钙化表面（四环素标记）也增加。皮质骨中的破骨细胞活性与游离甲状腺素指数以及尿钙和磷排泄呈正相关。这些发现表明，甲状腺功能亢进时的骨变化是特异性的，甲状腺激素刺激骨形成和吸收，随后皮质骨孔隙率增加和骨矿物质动员。
