Imaida K, Ishihara Y, Nishio O, Nakanishi K, Ito N
Toxicol Lett. 1983 May;16(3-4):259-69. doi: 10.1016/0378-4274(83)90186-8.
p-Phenylenediamine, an intermediate of oxidative-type hair dyes, was administered to groups of male and female F344 rats in their diet. A subacute toxicity test showed that 0.4% p-phenylenediamine was very toxic to both sexes, but that 0.2, 0.1 and 0.05% p-phenylenediamine induced no remarkable toxic changes in either sex. In a chronic toxicity test 0.1 and 0.05% p-phenylenediamine were given to both sexes in their diet for 80 weeks, but no carcinogenic effects were found in either sex.
对苯二胺是氧化型染发剂的一种中间体，将其添加到雄性和雌性F344大鼠的饮食中。亚急性毒性试验表明，0.4%的对苯二胺对两性都具有高毒性，但0.2%、0.1%和0.05%的对苯二胺对两性均未引起明显的毒性变化。在慢性毒性试验中，给两性大鼠在饮食中添加0.1%和0.05%的对苯二胺，持续80周，但未发现两性中有致癌作用。
