小鼠胎儿睾丸的放射反应及其受MPG（2-巯基丙酰甘氨酸）的影响
Radioresponse of fetal testes of mice and its modification by MPG (2-mercaptopropionylglycine).
作者信息
Goyal P K, Dev P K
出版信息
Strahlentherapie. 1983 Apr;159(4):239-41.
PMID:6857738
Abstract
Radiosensitivity of the primordial germ cells and its protection was estimated from the surviving number of spermatids in the 6 weeks old testes of control and MPG-pretreated mice after intrauterine exposure to 0.5, 1.5 and 2.5 Gy60Co gamma rays during fetal growth period. Radiosensitivity of fetal testes was found to increase with the advent of embryonic age. Quantitatively, significant protection in testes weight and spermatids count was registered in the MPG-pretreated animals at all the 3 dose levels studied.
摘要
通过在胎儿生长期对对照组和经MPG预处理的小鼠进行宫内暴露于0.5、1.5和2.5 Gy 60Coγ射线后，根据6周龄睾丸中精子细胞的存活数量，评估原始生殖细胞的放射敏感性及其保护作用。发现胎儿睾丸的放射敏感性随着胚胎年龄的增加而增加。在数量上，在所研究的所有3个剂量水平下，经MPG预处理的动物在睾丸重量和精子细胞计数方面均有显著的保护作用。
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