Espinal E G, de Rey B M, Cabrini R L
Strahlentherapie. 1983 May;159(5):290-5.
The chronic effect of 2000 rd (20 Gy) of X-rays locally applied to the submandibular gland of Wistar young-adult male rats, was studied by stereology, and light and electron microscopic observations. They demonstrated that degenerative changes were observed during the first months after irradiation. Atrophic processes developed from 6 months onwards. In the acinar compartment, atrophy was progressive from the first months post-irradiation up to 9 months post-irradiation. Ductal cell membranes and mitochondrial damage were clearly detected at ultrastructural level. Nuclear fragmentation and secretory granules alterations were also frequently seen in the acinar compartment.
通过体视学、光镜和电镜观察，研究了对Wistar成年雄性幼鼠下颌下腺局部施加2000拉德（20戈瑞）X射线的慢性影响。结果表明，在照射后的最初几个月内观察到了退行性变化。萎缩过程从6个月起开始出现。在腺泡部分，从照射后第一个月到照射后9个月，萎缩呈进行性发展。在超微结构水平上清楚地检测到导管细胞膜和线粒体损伤。在腺泡部分也经常可见核碎裂和分泌颗粒改变。
