Norberg L E, Lundquist P G
Department of Otolaryngology, Linköping University Hospital, Sweden.
Arch Otorhinolaryngol. 1989;246(4):200-4. doi: 10.1007/BF00453662.
Rat submandibular glands were exposed to fractionated irradiation of 50 Gy, as given comparably in clinical practice. The induced changes were compared by giving only irradiation or radiation in conjunction with stimulating the salivary glands with cyclocytidine prior to treatment. Cyclocytidine is an alpha-adrenergic agonist that effectively depletes the serous cells of their granules and their heavy metal content. Findings in the present study show that the administration of the drug prior to each irradiation reduces the radiation-induced destruction in the epithelial cells in the submandibular gland.
将大鼠下颌下腺按照临床实践中的同等剂量进行50 Gy的分次照射。通过仅给予照射或在治疗前用环胞苷刺激唾液腺并结合照射来比较诱导的变化。环胞苷是一种α-肾上腺素能激动剂，可有效耗尽浆液细胞中的颗粒及其重金属含量。本研究结果表明，每次照射前给予该药物可减少下颌下腺上皮细胞的辐射诱导损伤。
