Gurian L, Klein K, Ward T T
West J Med. 1983 Mar;138(3):359-60.
Findings from recent studies on the role of Clostridium difficile and Campylobacter jejuni in exacerbations of inflammatory bowel disease are in conflict. We examined stool specimens from 32 patients who had inflammatory bowel disease in relapse for the presence of C difficile and C difficile cytotoxin. In the last 19 cases stool specimens were also cultured for C jejuni. C difficile was identified in one patient who was receiving antimicrobial therapy. In no patient was C difficile cytotoxin detected. All cultures for C jejuni were negative. Routine screening of stool specimens for C difficile cytotoxin and C jejuni was not clinically useful in our patients during exacerbation of their inflammatory bowel disease.
近期关于艰难梭菌和空肠弯曲菌在炎症性肠病病情加重中作用的研究结果相互矛盾。我们检查了32例炎症性肠病复发患者的粪便标本，以检测是否存在艰难梭菌和艰难梭菌细胞毒素。在最后19例病例中，粪便标本还进行了空肠弯曲菌培养。在一名接受抗菌治疗的患者中发现了艰难梭菌。未在任何患者中检测到艰难梭菌细胞毒素。所有空肠弯曲菌培养均为阴性。在我们的患者炎症性肠病病情加重期间，对粪便标本进行艰难梭菌细胞毒素和空肠弯曲菌的常规筛查在临床上并无用处。
