Wright J M, Adams S P, Gribble M J, Bowie W R
Can J Surg. 1984 Sep;27(5):435-7.
Clostridium difficile has been detected in the stools of some patients with relapse of Crohn's disease. The authors looked prospectively for present or previous exposure to C. difficile cytotoxin in 10 patients with mild to severe Crohn's disease. None of 25 stool samples from these 10 patients was positive for C. difficile cytotoxin. These negative stool ultrafiltrates had mild cytotoxin neutralizing activity, but this finding did not differ from that in 30 cytotoxin-negative stools from patients with other diarrheal diseases. Serum from these patients also showed no cytotoxin neutralizing activity. Review of the literature reveals that C. difficile can cause complications ranging from diarrhea to toxic megacolon in a small but variable proportion of patients with Crohn's disease. There is no evidence that C. difficile plays a part in the pathogenesis of the disease.
在一些克罗恩病复发患者的粪便中检测到了艰难梭菌。作者前瞻性地研究了10例轻至重度克罗恩病患者目前或既往是否接触过艰难梭菌细胞毒素。这10例患者的25份粪便样本中，没有一份艰难梭菌细胞毒素检测呈阳性。这些粪便超滤物呈阴性，但具有轻微的细胞毒素中和活性，不过这一发现与其他腹泻病患者的30份细胞毒素阴性粪便并无差异。这些患者的血清也未显示出细胞毒素中和活性。文献综述表明，在一小部分但比例各异的克罗恩病患者中，艰难梭菌可引发从腹泻到中毒性巨结肠等并发症。没有证据表明艰难梭菌在该疾病的发病机制中起作用。
