Wienbeck M, Erckenbrecht J, Strohmeyer G
Z Gastroenterol. 1983 Mar;21 Suppl:111-6.
Disturbances of gut motility occur frequently under a highdose antacid regimen. Typical symptoms are diarrhea and constipation. They are due to the cations of the antacids. Aluminum causes constipation, magnesium induces diarrhea, and calcium has no definite motor effect. The following mechanisms of action have to be taken into consideration: effects of the cations on the smooth muscle of the gut, on the enteric nervous system and on the release of gastrointestinal hormones as well as alterations of the physiochemical properties of the intraluminal contents. Aluminum inhibits the motor activity of the stomach and intestine, magnesium stimulates muscle contractions; however, the simultaneous activation of the intrinsic nerves, which are predominantly inhibitory, by magnesium may conceal the muscular effects of this cation. The diarrhea under a highdose regimen of antacid combinations appears to be due predominantly to the osmotic-secretory effects of the antacids.
在高剂量抗酸剂治疗方案下，肠道动力紊乱频繁发生。典型症状为腹泻和便秘。这些症状是由抗酸剂的阳离子引起的。铝导致便秘，镁引起腹泻，而钙对肠道运动没有明确影响。必须考虑以下作用机制：阳离子对肠道平滑肌、肠神经系统以及胃肠激素释放的影响，以及肠腔内内容物理化性质的改变。铝抑制胃和肠道的运动活性，镁刺激肌肉收缩；然而，镁同时激活主要起抑制作用的内在神经，可能会掩盖该阳离子的肌肉效应。高剂量抗酸剂组合治疗方案下的腹泻似乎主要是由抗酸剂的渗透分泌作用导致的。
