B淋巴细胞抗原在混合淋巴细胞培养刺激中的作用。
The role of B-lymphocyte antigens in MLC stimulation.
作者信息
Terasaki P I, Park M S, Opelz G, Saito S, Mickey M R
出版信息
Transplant Proc. 1977 Mar;9(1):469-73.
A total of 950 MLC combinations were set up out of which 259 were classified as low MLC response. An attempt was made to predict which of the combinations would give low response by matching the B-lymphocyte specificities and the HLA-A and -B antigens. A statistically significant prediction of a low response was noted for the B-lymphocyte specificities as well as for HLA-A and -B antigens. The fraction of the low response, which was correctly found, was, however, greater with the B-cell specificities than the HLA-A and -B locus antigens. It is concluded that the B-lymphocyte specificities may be either identical or closely linked to the DW specificities. To what extent they are associated with the strong transplantation antigens of man remains to be determined.
共设置了950种MLC组合，其中259种被归类为低MLC反应。通过匹配B淋巴细胞特异性以及HLA - A和 - B抗原，尝试预测哪些组合会产生低反应。对于B淋巴细胞特异性以及HLA - A和 - B抗原，均观察到低反应的统计学显著预测。然而，通过B细胞特异性正确发现的低反应比例高于HLA - A和 - B位点抗原。结论是B淋巴细胞特异性可能与DW特异性相同或紧密相连。它们与人的强移植抗原相关的程度仍有待确定。
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