Termijtelen A, van Rood J J
Scand J Immunol. 1981 Nov;14(5):459-66.
The influence of HLA-A and -B on primary mixed lymphocyte cultures (MLCs) was investigated in homozygous typing cell (HTC) experiments and by testing HLA-D/DR-identical, heterozygous individuals. Compatibility or identity for HLA-B between HLA-D-compatible or -identical responder and stimulator combinations resulted in lower MLC reactivity in many cases. Since this was especially true for haplotypes containing antigens with strong linkage disequilibrium, it was suggested that this observation was due to matching for antigens encoded by the B-D region rather than to matching for HLA-B itself. An additional influence of matching for HLA-A could not be demonstrated, possibly owing to the fact that stimulation caused by the HLA-A region is too weak to influence our results. The complexity of stimulation in MLC is discussed.
在纯合分型细胞（HTC）实验以及通过检测HLA-D/DR相同的杂合个体，研究了HLA-A和 -B对原发性混合淋巴细胞培养（MLC）的影响。在HLA-D相容或相同的反应者与刺激者组合中，HLA-B之间的相容性或一致性在许多情况下导致MLC反应性降低。由于对于含有具有强连锁不平衡抗原的单倍型尤其如此，因此有人提出，这一观察结果是由于B-D区域编码的抗原匹配，而不是由于HLA-B本身的匹配。未能证明HLA-A匹配的额外影响，这可能是由于HLA-A区域引起的刺激太弱，无法影响我们的结果。讨论了MLC中刺激的复杂性。
