Flage T
Acta Ophthalmol (Copenh). 1983 Feb;61(1):20-8. doi: 10.1111/j.1755-3768.1983.tb01390.x.
The effect of an intravenous injection of sodium iodate on the retinal pigment epithelium immediately surrounding the optic nerve head has been investigated using horseradish peroxidase as a morphological tracer. A sodium iodate injection leads to a necrotic reaction of practically the complete retinal pigment epithelium. The juxtapapillary pigment epithelium, however, showed only attenuation and depigmentation without any necrotic reaction 4 and 12 days after the injection. Twenty-six days following the injection the epithelium had almost normalized. The result of this study thus demonstrates a noteworthy resistance of the juxtapapillary retinal pigment epithelium against the sodium iodate effect. At no stage was there a clear indication of a breakdown of the permeability barrier constituted by the juxtapapillary retinal pigment epithelium. Horseradish peroxidase moved into the peripapillary sensory retina by lateral diffusion from the surrounding retina and diffused into the optic nerve head proper, confirming the presence of a diffusional pathway through the Kuhnt intermediary tissue.
使用辣根过氧化物酶作为形态学示踪剂，研究了静脉注射碘酸钠对视神经乳头周围视网膜色素上皮的影响。注射碘酸钠会导致几乎整个视网膜色素上皮发生坏死反应。然而，注射后4天和12天，视乳头周围色素上皮仅表现为变薄和色素脱失，无任何坏死反应。注射26天后，上皮几乎恢复正常。因此，本研究结果表明视乳头周围视网膜色素上皮对碘酸钠效应具有显著抗性。在任何阶段都没有明确迹象表明由视乳头周围视网膜色素上皮构成的通透性屏障遭到破坏。辣根过氧化物酶从周围视网膜通过侧向扩散进入视乳头周围的感觉视网膜，并扩散到视神经乳头本身，证实了存在一条通过昆特中间组织的扩散途径。
