Ashburn F S, Pilkerton A R, Rao N A, Marak G E
Invest Ophthalmol Vis Sci. 1980 Dec;19(12):1427-32.
Sodium iodate and sodium iodoacetate were employed as biological probes to evaluate component forces contributing to the strength of retinal adhesion to the retinal pigment epithelium (RPE). Iodate treatment produced a rapid reduction in the strength of adhesion, which was complete within 1 hr without evidence of concurrent structural change. The adhesive strength reduction produced by iodoacetate required 8 to 12 hr, corresponding to the appearance of early structural changes in the photoreceptor outer segments, although delayed metabolic disturbances in the RPE might also have been involved. The study suggests that metabolic activity in the RPE may account for a portion of the strength of adhesion and that structural changes in the photoreceptor outer segments may also contribute to the forces of adhesion.
碘酸钠和碘乙酸钠被用作生物探针，以评估促成视网膜与视网膜色素上皮（RPE）之间粘连强度的组成力。碘酸盐处理使粘连强度迅速降低，在1小时内完成，且无同时发生结构变化的迹象。碘乙酸产生的粘连强度降低需要8至12小时，这与光感受器外段早期结构变化的出现相对应，尽管RPE中延迟的代谢紊乱可能也有涉及。该研究表明，RPE中的代谢活性可能占粘连强度的一部分，并且光感受器外段的结构变化也可能对粘连力有贡献。
