Cole A, May P M, Williams D R
Agents Actions. 1983 Feb;13(1):91-7. doi: 10.1007/BF01994289.
Formation constants for copper(II) and zinc(II) complexes of isonicotinoylhydrazine (isoniazid) and guanosine-5'-monophosphate have been measured potentiometrically at 37 degrees C, I = 150 mmol dm-3 [NaCl]. These constants have been used in computer models to assess the extent of complex formation by the drug in vivo. The simulations indicate that the predominant complexes existing in blood plasma are ternary species formed with histidinate. However, at clinical levels of isoniazid, it seems unlikely that these complexes are physiologically significant. On the other hand, ternary complex formation with nucleosides may be involved in the binding of isoniazid to viral RNA.
已在37℃、离子强度I = 150 mmol dm⁻³[NaCl]条件下，通过电位滴定法测定了异烟酰肼（异烟肼）和鸟苷-5'-单磷酸与铜（II）和锌（II）形成配合物的形成常数。这些常数已用于计算机模型，以评估该药物在体内形成配合物的程度。模拟结果表明，血浆中存在的主要配合物是与组氨酸形成的三元物种。然而，在异烟肼的临床剂量水平下，这些配合物似乎不太可能具有生理意义。另一方面，与核苷形成三元配合物可能参与异烟肼与病毒RNA的结合。
