Dearth J C, Tompkins R B, Giuliani E R, Feldt R H
Am J Dis Child. 1978 Sep;132(9):900-2. doi: 10.1001/archpedi.1978.02120340076016.
Gout is rarely noted as a clinical problem in secondary polycythemia-- even if profound polycythemia exists, as in cyanotic congenital heart disease. A retrospective study of 81 patients with congenital heart disease was done to assess the incidence of hyperuricemia. Twenty of 46 patients with cyanotic congenital heart disease had serum levels of uric acid greater than 8 mg/dl. Thirteen of 16 (81%) cyanotic male patients more than 15 years old had serum levels greater than 8 mg/dl. For cyanotic patients, serum levels of uric acid were related directly to the degree of polycythemia (r = .44; P less than .02). Impaired renal function or drug therapy did not seem to account for the hyperuricemia. Because levels of uric acid greater than 10 mg/dl probably are nephropathic, many of these patients may be incurring subclinical uric acid nephropathy.
痛风在继发性红细胞增多症中很少被视为临床问题——即便存在严重的红细胞增多症，如在青紫型先天性心脏病中。对81例先天性心脏病患者进行了一项回顾性研究，以评估高尿酸血症的发生率。46例青紫型先天性心脏病患者中有20例血清尿酸水平高于8mg/dl。16例年龄超过15岁的青紫型男性患者中有13例（81%）血清尿酸水平高于8mg/dl。对于青紫型患者，血清尿酸水平与红细胞增多症的程度直接相关（r = 0.44；P < 0.02）。肾功能受损或药物治疗似乎不能解释高尿酸血症。由于尿酸水平高于10mg/dl可能会导致肾病，这些患者中的许多人可能正在发生亚临床尿酸肾病。
