Newell L M, Malkinson F D
Arch Dermatol. 1983 Jun;119(6):495-7. doi: 10.1001/archderm.119.6.495.
A 46-year-old woman had a 17-year history of intermittently severe pyoderma gangrenosum without identifiable associated systemic disease. Her condition had become unresponsive to corticosteroid and sulfone therapy given for systemic effect, but responded completely to 150 mg/day of cyclophosphamide. Immunosuppressive therapy should be considered in patients with severe, recalcitrant pyoderma gangrenosum, even in the absence of associated systemic disease.
一名46岁女性有17年间歇性严重坏疽性脓皮病病史，未发现相关全身性疾病。她的病情对用于全身作用的皮质类固醇和砜类药物治疗无反应，但对每天150毫克环磷酰胺完全有反应。对于严重、顽固性坏疽性脓皮病患者，即使没有相关全身性疾病，也应考虑免疫抑制治疗。
