Department of Dermatology, Teaching Hospital, Kandy, Sri Lanka.
Int Wound J. 2010 Dec;7(6):519-23. doi: 10.1111/j.1742-481X.2010.00725.x. Epub 2010 Aug 17.
Oral phenytoin is an extensively used medicine for the treatment of convulsive disorders. Topical phenytoin has also been used for various types of ulcers. To determine the effectiveness of 2% topical phenytoin sodium solution in treating recalcitrant pyoderma gangrenosum. Six patients with treatment-resistant pyoderma gangrenosum who attended to Dermatology Unit/Ward were taken to the study and applied topical 2% phenytoin sodium solution to the wounds alone with other systemic therapy. Response to the treatment was assessed weekly. Three patients had idiopathic PG and other three had secondary diseases. At the end of the 4th week four patients showed complete resolution of the ulcers whereas other two patients showed the partial resolution. No adverse effects were noted. Phenytoin sodium 2% solution is beneficial for pyoderma gangrenosum (PG) with various etiologies. It enhanced the healing of the ulcer especially when the patient has treatment resistant disease.
口服苯妥英钠是一种广泛用于治疗惊厥性疾病的药物。局部苯妥英钠也被用于治疗各种类型的溃疡。为了确定 2%局部苯妥英钠溶液治疗难治性坏疽性脓皮病的疗效，对皮肤科病房就诊的 6 例治疗抵抗性坏疽性脓皮病患者进行了研究，并单独使用其他全身治疗方法将 2%局部苯妥英钠溶液应用于伤口。每周评估一次治疗反应。3 例患者为特发性 PG，另外 3 例患者为继发性疾病。在第 4 周结束时，4 例患者的溃疡完全愈合，而另外 2 例患者的溃疡部分愈合。未观察到不良反应。2%苯妥英钠溶液对各种病因的坏疽性脓皮病（PG）有益。它促进了溃疡的愈合，特别是当患者患有治疗抵抗性疾病时。
