Bankier A, Turner M, Hopkins I J
Arch Dis Child. 1983 Jun;58(6):415-8. doi: 10.1136/adc.58.6.415.
We report 4 infants with pyridoxine dependent seizures who had clinical features that led to diagnostic uncertainty. Their clinical course was unusual in 1 or more of the following: later onset of initial seizures; a seizure free period after taking of anticonvulsants, but before taking of pyridoxine; a long remission after withdrawal of pyridoxine; and atypical seizure type. This report illustrates a broader range of clinical features and highlights the need to consider the diagnosis of pyridoxine dependent seizures in any infant with intractable epilepsy, regardless of the pattern of seizures and the response to anticonvulsant medications. In such a case, 100 mg intravenous pyridoxine should be given and, if a definite clinical response is established, oral pyridoxine should be continued indefinitely.
我们报告了4例吡哆醇依赖性癫痫的婴儿，他们的临床特征导致诊断存在不确定性。他们的临床病程在以下1个或多个方面不寻常：首次发作较晚；服用抗惊厥药物后、服用吡哆醇前有一段无癫痫发作期；停用吡哆醇后有较长时间的缓解期；以及非典型癫痫发作类型。本报告说明了更广泛的临床特征，并强调对于任何患有难治性癫痫的婴儿，无论癫痫发作模式和对抗惊厥药物的反应如何，都需要考虑吡哆醇依赖性癫痫的诊断。在这种情况下，应静脉注射100 mg吡哆醇，如果确定有明确的临床反应，则应无限期持续口服吡哆醇。
