烧伤对替代补体途径的优先激活和消耗
Preferential activation and depletion of the alternative complement pathway by burn injury.
作者信息
Gelfand J A, Donelan M, Burke J F
出版信息
Ann Surg. 1983 Jul;198(1):58-62. doi: 10.1097/00000658-198307000-00011.
Abstract
Complement levels of eight adult burn patients (25% to 90% body surface area) were studied upon admission to a burn unit and sequentially for one week. Mean classical pathway titers (CH50) were 49% below the normal mean, while hemolytic C4 titers were reduced by 53% and C3 by 43%. However, the alternative pathway titer was reduced by more than 90%, suggesting preferential depletion of this pathway. This depletion was associated with sepsis, pneumonia, and "shock lung." Alternative pathway deficiency was still present one week postburn, and may contribute to the susceptibility of burn patients to bacterial sepsis.
摘要
对八名成年烧伤患者（烧伤面积为体表面积的25%至90%）入院时及随后一周内的补体水平进行了研究。经典途径平均滴度（CH50）比正常平均值低49%，而溶血C4滴度降低了53%，C3降低了43%。然而，替代途径滴度降低了90%以上，表明该途径优先被消耗。这种消耗与败血症、肺炎和“休克肺”有关。烧伤一周后替代途径缺乏仍然存在，这可能导致烧伤患者易患细菌性败血症。
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