Mellinger R C, Zafar M S
Arch Intern Med. 1983 Jun;143(6):1249-51. doi: 10.1001/archinte.143.6.1249.
A patient with lifelong severe polyuria and polydipsia had normal serum antidiuretic hormone (ADH) levels and responded to water deprivation with a prompt increase in urine osmolality and maintenance of normal plasma osmolality (less than 290 mOsm/kg), despite extreme thirst. When treated with desmopressin acetate and allowed free access to water, she was able to reduce plasma osmolality below 270 mOsm/kg, and her compelling thirst disappeared. The disorder is interpreted to be the result of excessive fluid intake in response to a thirst stimulus that was not inhibited by normal plasma osmolality. This study indicates that osmoreceptor control of ADH secretion is normal. Continued administration of vasopressin has relieved the symptoms and has not resulted in water intoxication.
一名患有终生严重多尿和烦渴的患者，其血清抗利尿激素（ADH）水平正常，在禁水时尿渗透压迅速升高，血浆渗透压维持正常（低于290 mOsm/kg），尽管极度口渴。当用醋酸去氨加压素治疗并允许自由饮水时，她能够将血浆渗透压降至270 mOsm/kg以下，强烈的口渴感消失。该疾病被解释为对正常血浆渗透压未抑制的口渴刺激过度饮水的结果。本研究表明ADH分泌的渗透压感受器控制正常。持续给予血管加压素已缓解症状，且未导致水中毒。
