Hartmann O, Scopinaro M, Tournade M F, Sarrazin D, Lemerle J
Arch Fr Pediatr. 1983 Jan;40(1):15-21.
From 1975 to 1979, 173 children with neuroblastoma were treated according to the same protocol at the Institut Gustave-Roussy. They were classified according to the site of the primary tumor (abdominal: 122; thoracic: 29; others: 22) and according to TNM staging (stage I: 8; stage II: 24; stage III: 35; stage IV: 99; stage V: 2). Depending on stage and age, treatment consisted of surgery and radiotherapy associated with cyclic multiagent chemotherapy (vincristine, Adriamycin, cyclophosphamide). It resulted in a significant improvement of prognosis in stage III patients, especially those with abdominal tumors. In the latter group, prognosis depended mainly on the possibilities of resection of the tumors. Therefore, making these tumors operable remains the major goal of therapy in such patients. Radiotherapy is quite efficient in sterilizing the small post-surgical residual tumors. Prognosis in children over 1 year of age with metastases still remains very poor, even though the quality of the survival is improved.
1975年至1979年期间，古斯塔夫 - 鲁西研究所按照相同方案对173例神经母细胞瘤患儿进行了治疗。他们根据原发肿瘤部位（腹部：122例；胸部：29例；其他：22例）以及TNM分期进行分类（I期：8例；II期：24例；III期：35例；IV期：99例；V期：2例）。根据分期和年龄，治疗包括手术、放疗以及联合多药化疗（长春新碱、阿霉素、环磷酰胺）。这使得III期患者的预后有了显著改善，尤其是腹部肿瘤患者。在后者这组中，预后主要取决于肿瘤的切除可能性。因此，使这些肿瘤可切除仍然是此类患者治疗的主要目标。放疗在消除术后小的残留肿瘤方面相当有效。尽管生存质量有所提高，但1岁以上有转移的儿童预后仍然很差。
