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马兜铃酸所致大鼠前胃癌的组织病理学发生机制

On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid.

作者信息

Mengs U

出版信息

Arch Toxicol. 1983 Mar;52(3):209-20. doi: 10.1007/BF00333900.

DOI:10.1007/BF00333900
PMID:6860143
Abstract

The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.

摘要

研究了用马兜铃酸实验诱导大鼠前胃癌的组织病理发生过程。胃内给予10毫克/千克/天会导致鳞状上皮广泛坏死，随后是再生和增生、乳头状瘤形成，最终发展为浸润性鳞状细胞癌。

相似文献

1
On the histopathogenesis of rat forestomach carcinoma caused by aristolochic acid.马兜铃酸所致大鼠前胃癌的组织病理学发生机制
Arch Toxicol. 1983 Mar;52(3):209-20. doi: 10.1007/BF00333900.
2
Effect of diallyl sulfide on aristolochic acid-induced forestomach carcinogenesis in rats.二烯丙基硫醚对大鼠马兜铃酸诱导的前胃癌变的影响。
Carcinogenesis. 1993 Mar;14(3):407-10. doi: 10.1093/carcin/14.3.407.
3
Acute toxicity of aristolochic acid in rodents.马兜铃酸对啮齿动物的急性毒性。
Arch Toxicol. 1987 Feb;59(5):328-31. doi: 10.1007/BF00295084.
4
Aristolochic acid activates ras genes in rat tumors at deoxyadenosine residues.马兜铃酸在脱氧腺苷残基处激活大鼠肿瘤中的ras基因。
Cancer Res. 1990 Sep 1;50(17):5464-9.
5
Tumour induction in mice following exposure to aristolochic acid.小鼠暴露于马兜铃酸后诱发肿瘤的情况。
Arch Toxicol. 1988;61(6):504-5. doi: 10.1007/BF00293699.
6
Para-methoxyphenol strongly stimulates cell proliferation in the rat forestomach but is not a promoter of rat forestomach carcinogenesis.对甲氧基苯酚能强烈刺激大鼠前胃的细胞增殖，但不是大鼠前胃癌变的促进剂。
Carcinogenesis. 1990 Oct;11(10):1891-4. doi: 10.1093/carcin/11.10.1891.
7
Carcinogenicities of quinoline derivatives in F344 rats.喹啉衍生物在F344大鼠中的致癌性。
Cancer Lett. 1981 Nov;14(2):115-23. doi: 10.1016/0304-3835(81)90120-8.
8
Forestomach tumor induction by 2,4-hexadienal in F344N rats and B6C3F1 mice.2,4 -己二烯醛在F344N大鼠和B6C3F1小鼠中诱导前胃肿瘤
Arch Toxicol. 2003 Sep;77(9):511-20. doi: 10.1007/s00204-003-0481-8. Epub 2003 Jul 18.
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Influence of caffeic acid and other o-dihydroxybenzene derivatives on N-methyl-N'-nitro-N-nitrosoguanidine-initiated rat forestomach carcinogenesis.咖啡酸及其他邻二羟基苯衍生物对N-甲基-N'-硝基-N-亚硝基胍诱发的大鼠前胃癌变的影响。
Carcinogenesis. 1992 Oct;13(10):1825-8. doi: 10.1093/carcin/13.10.1825.
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Regression of simple hyperplasia and papillomas and persistence of basal cell hyperplasia in the forestomach of F344 rats treated with butylated hydroxyanisole.用丁基羟基茴香醚处理的F344大鼠前胃中单纯性增生和乳头状瘤的消退以及基底细胞增生的持续存在。
Cancer Res. 1987 Oct 1;47(19):5171-4.

引用本文的文献

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Nat Rev Cancer. 2022 Oct;22(10):576-591. doi: 10.1038/s41568-022-00494-x. Epub 2022 Jul 19.
2
QuEChERS pretreatment combined with high-performance liquid chromatography-tandem mass spectrometry for determination of aristolochic acids I and II in Chinese herbal patent medicines.QuEChERS预处理结合高效液相色谱-串联质谱法测定中成药中马兜铃酸I和II
RSC Adv. 2020 Jul 3;10(42):25319-25324. doi: 10.1039/d0ra03200j. eCollection 2020 Jun 29.
3
Defining in vivo dose-response curves for kidney DNA adduct formation of aristolochic acid I in rat, mouse and human by an in vitro and physiologically based kinetic modeling approach.

本文引用的文献

1
Notes on twenty-two Spontaneous tumors in Wild Rats (M. Norvegicus).关于野生大鼠（褐家鼠）二十二例自发性肿瘤的记录
J Med Res. 1911 Sep;25(1):205-216.1.
2
A Preliminary Report on tumors found in Wild Rats.关于在野生大鼠身上发现的肿瘤的初步报告。
J Med Res. 1909 Sep;21(2):285-96.
3
Spontaneous tumors in two colonies of rats of the Wistar Institute of Anatomy and Biology.解剖学与生物学威斯塔研究所的两个大鼠群体中的自发性肿瘤。
采用体外和基于生理学的动力学建模方法，定义马兜铃酸 I 在大鼠、小鼠和人体内肾脏 DNA 加合物形成的体内剂量反应曲线。
J Appl Toxicol. 2020 Dec;40(12):1647-1660. doi: 10.1002/jat.4024. Epub 2020 Jul 7.
4
Balkan endemic nephropathy and aristolochic acid I: an investigation into the role of soil and soil organic matter contamination, as a potential natural exposure pathway.巴尔干地方性肾病和马兜铃酸 I：土壤和土壤有机物污染的作用研究，作为一种潜在的自然暴露途径。
Environ Geochem Health. 2018 Aug;40(4):1437-1448. doi: 10.1007/s10653-017-0065-9. Epub 2017 Dec 29.
5
Revealing a Pre-neoplastic Renal Tubular Lesion by p-S6 Protein Immunohistochemistry after Rat Exposure to Aristolochic Acid.大鼠接触马兜铃酸后通过p-S6蛋白免疫组化揭示癌前肾小管病变
J Kidney Cancer VHL. 2015 Sep 8;2(4):153-162. doi: 10.15586/jkcvhl.2015.38. eCollection 2015.
6
Role of hepatic cytochrome P450 enzymes in the detoxication of aristolochic acid I; effects on DNA adduct, mutation, and tumor formation.肝细胞色素P450酶在马兜铃酸I解毒中的作用；对DNA加合物、突变和肿瘤形成的影响。
Genes Environ. 2015 Jul 30;37:11. doi: 10.1186/s41021-015-0010-z. eCollection 2015.
7
Evaluating weight of evidence in the mystery of Balkan endemic nephropathy.评估巴尔干地方性肾病之谜中的证据权重。
Risk Anal. 2014 Sep;34(9):1688-705. doi: 10.1111/risa.12239. Epub 2014 Jun 20.
8
Analysis of TP53 mutation spectra reveals the fingerprint of the potent environmental carcinogen, aristolochic acid.分析 TP53 突变谱揭示了强效环境致癌物马兜铃酸的指纹图谱。
Mutat Res. 2013 Jul-Sep;753(1):41-49. doi: 10.1016/j.mrrev.2013.02.003. Epub 2013 Feb 17.
9
Genetic loci that affect aristolochic acid-induced nephrotoxicity in the mouse.影响小鼠马兜铃酸肾病毒性的遗传位点。
Am J Physiol Renal Physiol. 2011 Jun;300(6):F1360-7. doi: 10.1152/ajprenal.00716.2010. Epub 2011 Mar 23.
10
Detoxification of aristolochic acid I by O-demethylation: less nephrotoxicity and genotoxicity of aristolochic acid Ia in rodents.马兜铃酸 I 的 O-去甲基化解毒：马兜铃酸 Ia 在啮齿类动物中的肾毒性和遗传毒性降低。
Int J Cancer. 2010 Sep 1;127(5):1021-7. doi: 10.1002/ijc.25141.
Am J Pathol. 1940 May;16(3):237-254.1.
4
Morbid anatomy, histopathology, and histopathogenesis of fore-stomach carcinoma in mice fed carcinogenic hydrocarbons in oil emulsions.给小鼠喂食油乳剂中致癌性碳氢化合物后前胃癌的病理解剖、组织病理学及组织发病机制
J Natl Cancer Inst. 1949 Aug;10(1):147-66.
5
[Vergleich der genotoxischen Aktivität von Aristolochiasäure in verschiedenen Testsystemen].[不同测试系统中马兜铃酸的遗传毒性活性比较]
Planta Med. 1982 Jul;45(3):136. doi: 10.1055/s-2007-971277.
6
Histopathogenesis of squamous-cell carcinoma induced in the forestomach of mice by intramural injection of 20-methylcholanthrene.通过向小鼠前胃壁内注射20-甲基胆蒽诱导的鳞状细胞癌的组织病理学发生机制。
J Natl Cancer Inst. 1951 Dec;12(3):491-531.
7
[THE CYTOGENESIS OF FORESTOMACH CARCINOMA IN RATS CAUSED BY N-METHYL-N-NITROSOURETHANE. (MORPHOLOGIC, CYTOPHOTOMETRIC AND AUTORADIOGRAPHIC STUDIES)].[N-甲基-N-亚硝基脲烷诱发大鼠前胃癌的细胞发生。（形态学、细胞光度学及放射自显影研究）]
Beitr Pathol Anat. 1965 Jan;131:63-120.
8
ARISTOLOCHIC ACID (NSC-50413): PHASE I CLINICAL STUDY.马兜铃酸（NSC - 50413）：I期临床研究。
Cancer Chemother Rep. 1964 Nov;42:35-7.
9
ARISTOLOCHIC ACID INTOXICATION: A NEW TYPE OF IMPAIRMENT OF URINARY CONCENTRATING ABILITY.马兜铃酸中毒：一种新型的尿浓缩能力损害。
Arch Int Pharmacodyn Ther. 1963 Oct 1;145:334-55.
10
TUMOR INHIBITORS. I. ARISTOLOCHIC ACID, THE ACTIVE PRINCIPLE OF ARISTOLOCHIA INDICA.肿瘤抑制剂。一、马兜铃酸，印度马兜铃的活性成分。
J Med Pharm Chem. 1962 May;5:657-9. doi: 10.1021/jm01238a029.