马兜铃酸所致大鼠前胃癌的组织病理学发生机制

Arch Toxicol. 1983 Mar;52(3):209-20. doi: 10.1007/BF00333900.

The histopathogenesis of rat forestomach carcinoma induced experimentally with aristolochic acid was investigated. The intragastric administration of 10 mg/kg/day caused extensive necrosis of the squamous epithelium, followed by regeneration and hyperplasia, papilloma formation and ultimately by invasive squamous cell carcinoma.

研究了用马兜铃酸实验诱导大鼠前胃癌的组织病理发生过程。胃内给予10毫克/千克/天会导致鳞状上皮广泛坏死，随后是再生和增生、乳头状瘤形成，最终发展为浸润性鳞状细胞癌。