大鼠中丙烯醛代谢的新途径。
A new pathway of acrolein metabolism in rats.
作者信息
Draminski W, Eder E, Henschler D
出版信息
Arch Toxicol. 1983 Mar;52(3):243-7. doi: 10.1007/BF00333903.
PMID:6860146
Abstract
The excretion of metabolites of acrolein in rat urine after single oral administration of 10 mg/kg was investigated. S-Carboxyethylmercapturic acid (S-carboxyethyl-N-acetyl-cysteine), or S-(propionic acid methyl ester)mercapturic acid, was found as the major metabolite. An unidentified metabolite was found in expired air. Acrylic acid and methyl acrylate are suggested as intermediates in the metabolism of acrolein.
摘要
研究了大鼠单次口服10mg/kg丙烯醛后其尿液中代谢产物的排泄情况。发现S-羧乙基巯基尿酸（S-羧乙基-N-乙酰半胱氨酸）或S-（丙酸甲酯）巯基尿酸是主要代谢产物。在呼出气体中发现了一种未鉴定的代谢产物。提示丙烯酸和丙烯酸甲酯是丙烯醛代谢的中间产物。
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