大脑5-羟色胺与习得性惩罚抵抗
Brain 5-hydroxytryptamine and learned resistance to punishment.
作者信息
Davis N M, Gray J A
出版信息
Behav Brain Res. 1983 May;8(2):129-37. doi: 10.1016/0166-4328(83)90049-9.
PMID:6860457
Abstract
Rats can learn to persist in making a response that is punished. Brain 5-hydroxytryptamine (5-HT) systems are known to mediate acute responding to punishment. This work investigates 5-HT involvement in learned resistance to punishment. Forebrain 5-HT was depleted by intracerebral injection of 5,7-dihydroxytryptamine. Lesioned rats were fully able to learn resistance to punishment, although acute responding to punishment was impaired. Forebrain 5-HT does not mediate learned resistance to punishment.
摘要
大鼠能够学会坚持做出受惩罚的反应。已知大脑5-羟色胺（5-HT）系统介导对惩罚的急性反应。这项研究调查了5-HT在习得性惩罚抵抗中的作用。通过脑内注射5,7-二羟基色胺耗尽前脑5-HT。尽管对惩罚的急性反应受损，但受损大鼠完全能够学会抵抗惩罚。前脑5-HT并不介导习得性惩罚抵抗。
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