Ogren S O, Johansson C, Magnusson O
Neurosci Lett. 1985 Aug 5;58(3):305-9. doi: 10.1016/0304-3940(85)90071-0.
The one-way active avoidance deficit caused by the serotonergic (5-HT) releasing compound p-chloroamphetamine (PCA) was examined in rats after degeneration of 5-HT neurons in the forebrain. Injection of 5,7-dihydroxytryptamine (5,7-DHT) into the forebrain in desipramine (20 mg/kg)-pretreated rats resulted in a 65-70% decrease in 5-HT concentrations in the prefrontal cortex and hippocampus without any significant effect on striatal 5-HT. Slight reductions in noradrenaline (NA) (25%) and dopamine (DA) (34%) concentrations were observed in the prefrontal cortex only. The 5,7-DHT lesions markedly attenuated the impaired avoidance performance induced by PCA (2.5 mg/kg), suggesting that the avoidance deficit depends on intact 5-HT terminals in cortex and/or hippocampus. The 5,7-DHT lesion alone caused a slight but significant impairment of acquisition. The results suggest that 5-HT terminal systems in the forebrain play an important role in avoidance learning.
在前脑5-羟色胺（5-HT）能神经元变性后的大鼠中，研究了5-HT释放化合物对氯苯丙胺（PCA）引起的单向主动回避缺陷。在接受去甲丙咪嗪（20毫克/千克）预处理的大鼠中，向前脑注射5,7-二羟基色胺（5,7-DHT）导致前额叶皮质和海马体中5-HT浓度降低65%-70%，而对纹状体5-HT没有任何显著影响。仅在前额叶皮质中观察到去甲肾上腺素（NA）（25%）和多巴胺（DA）（34%）浓度略有降低。5,7-DHT损伤显著减轻了PCA（2.5毫克/千克）诱导的回避行为受损，表明回避缺陷取决于皮质和/或海马体中完整的5-HT终末。单独的5,7-DHT损伤导致习得有轻微但显著的损害。结果表明，前脑的5-HT终末系统在回避学习中起重要作用。
