Runnebaum B, Klinga K, Von Holst T, Junkermann H
Am J Obstet Gynecol. 1978 Jul 15;131(6):628-31. doi: 10.1016/0002-9378(78)90821-9.
Blood samples were collected prior to vaginal hysterectomy from nine women in the proliferative phase of the cycle and from 15 women in the secretory phase, and from each uterus five grams of the fundus were obtained. The concentrations of progesterone (P), 20alpha-dihydroprogesterone (20alpha-DHP), estradiol-17beta (E2), and estriol (E3) were determined in serum and in the tissue with the use of specific radioimmunoassays. The concentrations of P and 20alpha-DHP in serum and myometrium were significantly higher in the secretory than in the proliferative phase. Furthermore, the concentration of P in myometrium was significantly higher than in serum in the secretory phase, indicating a specific uptake of P by the myometrium. The concentration of E2 was about 10 times higher in the myometrium than in the serum during both phases of the cycle and appeared to be independent of the serum levels. This indicates a specific but limited uptake of E2 by the myometrium. The E3 levels in the tissue showed no significant differences during the menstrual cycle, whereas in the serum the E3 concentrations were higher in the secretory than in the proliferative phase of the cycle.
在阴道子宫切除术之前，从处于月经周期增殖期的9名女性和分泌期的15名女性中采集血样，并从每个子宫获取5克子宫底部组织。使用特定的放射免疫分析法测定血清和组织中孕酮（P）、20α-二氢孕酮（20α-DHP）、雌二醇-17β（E2）和雌三醇（E3）的浓度。分泌期血清和子宫肌层中P和20α-DHP的浓度显著高于增殖期。此外，分泌期子宫肌层中P的浓度显著高于血清中的浓度，表明子宫肌层对P有特异性摄取。在月经周期的两个阶段，子宫肌层中E2的浓度均比血清中高约10倍，且似乎与血清水平无关。这表明子宫肌层对E2有特异性但有限的摄取。组织中的E3水平在月经周期中无显著差异，而血清中E3的浓度在分泌期高于增殖期。
