Batra S, Bengtsson L P
J Clin Endocrinol Metab. 1978 Apr;46(4):622-6. doi: 10.1210/jcem-46-4-622.
17 beta-Estradiol (E2) and progesterone (P) concentrations in blood and in the myometrium of human pregnancy at term (n=33) and in a few samples (n=5) around midterm of pregnancy were determined. E2 concentration in the myometrium (per g wet wt) at midterm was lower than the concentration in the plasma (per ml) so that the myometrium to plasma (My:Pl) ratio was 0.7. Relative to plasma concentration, the myometrial E2 increased little from midterm to term so that My:Pl was only 0.2 at term. Although P concentration in the myometrium was much greater than that in the plasma at midterm, My:Pl ratio being 2.2, it was lower than that in plasma at term so that My:Pl ratio was only 0.6. A fairly good correlation between plasma steroids and the myometrial steroids was observed at midterm but was distorted at term, probably due to saturation of the tissue-binding capacity. Steroid concentrations determined on the basis of protein showed a good correlation to the values expressed on the basis of wet weight. Whereas myometrial E2 concentration was significantly influenced by the distance from placenta, P concentration was not.
测定了足月妊娠（n = 33）时人子宫肌层及血液中的17β - 雌二醇（E2）和孕酮（P）浓度，以及妊娠中期前后少量样本（n = 5）中的上述激素浓度。妊娠中期子宫肌层中E2浓度（每克湿重）低于血浆中浓度（每毫升），子宫肌层与血浆的比例（My:Pl）为0.7。相对于血浆浓度，子宫肌层E2从妊娠中期到足月时增加很少，足月时My:Pl仅为0.2。尽管妊娠中期子宫肌层中P浓度远高于血浆中浓度，My:Pl比例为2.2，但足月时低于血浆中浓度，My:Pl比例仅为0.6。在妊娠中期观察到血浆类固醇与子宫肌层类固醇之间有相当好的相关性，但在足月时相关性被扭曲，可能是由于组织结合能力饱和。基于蛋白质测定的类固醇浓度与基于湿重表示的值有良好的相关性。子宫肌层E2浓度受距胎盘距离的显著影响，而P浓度则不受影响。
