Davies B, Watt D A, Daggett A
Br Heart J. 1983 Jul;50(1):65-9. doi: 10.1136/hrt.50.1.65.
The response of total creatine kinase (CK) and the creatine kinase isoenzyme (CK MB) was studied in 22 male post-infarction patients (three to six months after myocardial infarction) after a functional graded exercise test, before entering a rehabilitation programme. Eleven subjects (group A) completed the test without developing significant electrocardiographic abnormalities. Eleven subjects (group B) showed changes that necessitated premature termination of the test. No significant differences were observed before the functional graded exercise test between the groups in serum concentration of CK, CK MB, and the percentage of CK MB to CK (MB/ CK%). The two groups were significantly different (p less than 0.01) 24 hours after the graded exercise test in CK MB and MB/CK%, but not in CK. In group B, CK and CK MB rose significantly after the graded exercise test (p less than 0.05) as did MB/CK% (p less than 0.01). In group A only CK showed a significant rise (p less than 0.05). It is probable that increases in CK MB after exercise arise from myocardial tissue efflux, reflecting reversible ischaemia. It is concluded from this study that CK MB appears to be a specific indicator of myocardial ischaemia and could, therefore, be of significant assistance in the clinical and functional assessment of the post-infarction patient.
在22名男性心肌梗死后患者（心肌梗死后三至六个月）进入康复计划之前，在进行分级运动功能试验后，研究了总肌酸激酶（CK）和肌酸激酶同工酶（CK MB）的反应。11名受试者（A组）完成了试验，未出现明显的心电图异常。11名受试者（B组）出现了需要提前终止试验的变化。在分级运动功能试验前，两组在CK、CK MB的血清浓度以及CK MB占CK的百分比（MB/CK%）方面未观察到显著差异。在分级运动试验后24小时，两组在CK MB和MB/CK%方面存在显著差异（p小于0.01），但在CK方面无差异。在B组中，分级运动试验后CK、CK MB显著升高（p小于0.05），MB/CK%也显著升高（p小于0.01）。在A组中，只有CK显著升高（p小于0.05）。运动后CK MB升高可能源于心肌组织外流，反映了可逆性缺血。从这项研究得出的结论是，CK MB似乎是心肌缺血的一个特异性指标，因此在心肌梗死后患者的临床和功能评估中可能会有很大帮助。
