肌酸激酶同工酶MB及CK/GOT比值在急性心肌梗死鉴别诊断中的应用（作者译）

[Creatine kinase isoenzyme MB and CK/GOT-ratio in the differential diagnosis of acute myocardial infarction (author's transl)].

作者信息

Schmidt E W, Wellstein A, Moll A

出版信息

Med Klin. 1977 Sep 2;72(35):1368-71.

Abstract

In 56 patients with certain transmural myocardial infarction the reliability of myocard specific creatine kinase isoenzyme MB is compared with the usual estimation of creatine kinase activity in serum and the use of CK/GOT activity quotient. In measurements at different times CK-MB proves to be more reliable than other laboratory parameters: during the first 24 hours after hospital admission CK-MB indicates the infarct and correlates with ECG alterations in practically all cases. In 11 patients with CK-activity increase over 100 U/l of extracardial origin, myocardial involvement can be excluded by measuring CK-MB-activity. Formation of CK/GOT quotient shows erroneously an infarction in about half the cases.

摘要

在56例确诊为透壁性心肌梗死的患者中，将心肌特异性肌酸激酶同工酶MB的可靠性与血清中肌酸激酶活性的常规测定以及CK/GOT活性比值的应用进行了比较。在不同时间的测量中，CK-MB被证明比其他实验室参数更可靠：在入院后的头24小时内，CK-MB可显示梗死情况，并且在几乎所有病例中都与心电图改变相关。在11例心外源性CK活性升高超过100 U/l的患者中，通过测量CK-MB活性可排除心肌受累情况。CK/GOT比值的形成在约一半的病例中错误地显示为梗死。