银屑病中多形核白细胞反应的改变：趋化作用和脱颗粒作用。

Altered polymorphonuclear leukocyte responses in psoriasis: chemotaxis and degranulation.

作者信息

Preissner W C, Schröder J M, Christophers E

出版信息

Br J Dermatol. 1983 Jul;109(1):1-8. doi: 10.1111/j.1365-2133.1983.tb03984.x.

DOI:10.1111/j.1365-2133.1983.tb03984.x

Abstract

Chemotactic activities of circulating polymorphonuclear leukocytes (PMN) were determined in twenty patients with psoriasis and twenty healthy control persons. After serial dilution of the complement split product C5a and the formylated tripeptide f-met-leu-phe (FMLP), chemotaxis profiles showed that PMN migration toward both chemotaxins was significantly increased in psoriasis. In addition, PMN from psoriatic patients responded to chemotaxins at much lower concentrations compared with controls. The liberation of (lysosomal) beta-glucuronidase was also determined in cytochalasin B-treated cells confronted with increased concentrations of the chemotaxins. Secretion of this marker enzyme started at lower concentrations in PMN derived from psoriatic patients. Our observations demonstrate migratory and secretory hyper-responsiveness of PMN from psoriatic patients. This may play a role in perpetuating the psoriatic tissue reaction.

摘要

在20例银屑病患者和20名健康对照者中测定了循环多形核白细胞（PMN）的趋化活性。在对补体裂解产物C5a和甲酰化三肽f-甲硫-亮-苯丙氨酸（FMLP）进行系列稀释后，趋化性分析表明，银屑病患者中PMN向这两种趋化因子的迁移均显著增加。此外，与对照组相比，银屑病患者的PMN对趋化因子的反应浓度要低得多。还在面对趋化因子浓度增加的细胞松弛素B处理的细胞中测定了（溶酶体）β-葡萄糖醛酸酶的释放。这种标记酶在银屑病患者来源的PMN中以较低浓度开始分泌。我们的观察结果表明银屑病患者的PMN具有迁移和分泌高反应性。这可能在银屑病组织反应的持续存在中起作用。