Christophers E, Henseler T
Department of Dermatology, University of Kiel, Federal Republic of Germany.
Arch Dermatol Res. 1987;279 Suppl:S48-51. doi: 10.1007/BF00585919.
In this report we investigate the simultaneous occurrence of psoriasis and atopic dermatitis (AD) as well as the association with infectious skin diseases. Among 29,159 patients hospitalized between 1953 and 1983, 8.5% (2,467 patients) were treated for psoriasis, while 1.6% (470 patients) were hospitalized for AD treatment. On the basis of incidence rates for both diseases, 36 patients (0.14%) with both psoriasis and AD were expected to be seen. However, the two conditions were simultaneously present in 2 patients only. Approximately 30% of the AD patients were suffering from either bacterial or viral infection, while this complication occurred in 6.7% of psoriatics. In addition, among 48 patients hospitalized for eczema herpeticatum 39 were atopics and none was psoriatic. The data demonstrate that the occurrence of psoriasis and AD in one and the same patient is quite rare and this may be related to conflicting immune defense patterns. Thus, increased sensitization against foreign protein together with high susceptibility to cutaneous infection present in AD is in contrast to high phagocyte responsiveness in psoriasis, where concurrent infections are rare.
在本报告中，我们研究了银屑病与特应性皮炎（AD）的同时发生情况以及与感染性皮肤病的关联。在1953年至1983年间住院的29159名患者中，8.5%（2467名患者）接受了银屑病治疗，而1.6%（470名患者）因AD治疗住院。根据两种疾病的发病率，预计会有36名（0.14%）同时患有银屑病和AD的患者。然而，仅2名患者同时存在这两种情况。约30%的AD患者患有细菌或病毒感染，而这种并发症在6.7%的银屑病患者中出现。此外，在因疱疹样湿疹住院的48名患者中，39名是特应性体质，无一名是银屑病患者。数据表明，同一患者同时发生银屑病和AD相当罕见，这可能与相互冲突的免疫防御模式有关。因此，AD中对外源蛋白的致敏性增加以及对皮肤感染的高易感性与银屑病中吞噬细胞反应性高形成对比，银屑病并发感染很少见。
