Rupp W, Badian M, Dagrosa E, Ganshorn F, Lucena M, Petri W, Sittig W
Br J Dermatol. 1983 Jul;109 Suppl 25:111-3. doi: 10.1111/j.1365-2133.1983.tb06818.x.
In the expanding field of clinical dermatopharmacology we standardized an erythema model for testing drugs with effects on UV-induced inflammation in normal male Caucasian subjects. Using a light source with fibre-optic transmission and precise radiation characteristics, some of the shortcomings of conventional UV-application could be overcome. The radiation geometry during the various experiments was kept constant by a tube, permitting a defined area of exposure. Up to eight skin areas of the backs of normal volunteers were radiated with 86.2% UV-A and 13.8% UV-B. After exclusion of hyporeactive and hyperreactive subjects a good intrasubject reproducibility was obtained repeatedly over at least 3 months. According to the definition of bioavailability, our method allows the measurement of the rate and extent of UV-induced erythema. This model has been used for testing topical steroids, non-steroidal antiphlogistics in a variety of pharmaceutical formulations.
在不断发展的临床皮肤药理学领域，我们为测试对正常白种男性受试者紫外线诱导炎症有影响的药物标准化了一种红斑模型。通过使用具有光纤传输和精确辐射特性的光源，传统紫外线照射的一些缺点得以克服。在各种实验过程中，通过一根管子保持辐射几何形状恒定，从而允许有一个确定的暴露区域。正常志愿者背部多达八个皮肤区域接受86.2%的紫外线A和13.8%的紫外线B照射。在排除反应低下和反应亢进的受试者后，至少在3个月内反复获得了良好的受试者内重现性。根据生物利用度的定义，我们的方法允许测量紫外线诱导红斑的速率和程度。该模型已用于测试各种药物制剂中的局部类固醇、非甾体抗炎药。
