Worthington D, Piercy W N, Smith B T
Am J Obstet Gynecol. 1978 Aug 1;131(7):749-54. doi: 10.1016/0002-9378(78)90239-9.
Chronic maternal administration of diazepam resulted in a modification of fetal respiratory-like activity (FRLA) in the sheep. An over-all increase in this activity occurred. This increase was probably due to a rebound effect following periods of acute suppression with each administration of diazepam. Loss of central control in the regulation of FRLA was implied. A complete reversal of a circadian rhythm of FRLA was observed in animals receiving diazepam. These changes have implications with respect to the antenatal monitoring of the fetus and sequelae in the newborn infant.
孕期长期使用地西泮会改变绵羊胎儿的类呼吸活动（FRLA）。这种活动总体上有所增加。这种增加可能是由于每次使用地西泮后急性抑制期后的反跳效应。这意味着在FRLA调节中失去了中枢控制。在接受地西泮的动物中观察到FRLA昼夜节律完全逆转。这些变化对胎儿的产前监测及新生儿后遗症具有重要意义。
