Adams G A, Brown S J, McIntire L V, Eskin S G, Martin R R
Blood. 1983 Jul;62(1):69-74.
Epifluorescent microscopy was used to monitor the adhesion of platelets and the growth of platelet aggregates on collagen-coated glass tubes perfused with whole blood. The maximum basal length and width of the aggregate size increased linearly with time, growing symmetrically transverse to the direction of flow and asymmetrically in the plane longitudinal to the direction of flow. Aggregates had elliptical bases, with the major axis parallel to the direction of blood flow. These studies provide an experimental approach to studies of the kinetics of platelet interaction with artificial surfaces and give further support to the concept that blood flow has a major effect on the development of platelet thrombi.
采用落射荧光显微镜监测血小板在灌注全血的胶原包被玻璃管上的黏附以及血小板聚集体的生长情况。聚集体大小的最大基底长度和宽度随时间呈线性增加，在垂直于血流方向上对称生长，而在平行于血流方向的平面内不对称生长。聚集体具有椭圆形基底，其长轴平行于血流方向。这些研究为血小板与人工表面相互作用动力学的研究提供了一种实验方法，并进一步支持了血流对血小板血栓形成有重大影响这一概念。
