Helke C J, Handelmann G E, Jacobowitz D M
Brain Res Bull. 1983 Apr;10(4):433-6. doi: 10.1016/0361-9230(83)90139-9.
The influence of nodose ganglionectomy or transection of the peripheral branches of the afferent vagus nerve on choline acetyltransferase (ChAT) activity in the nucleus tractus solitarius (NTS) was studied. ChAT activity was reduced in the microdissected caudal and intermediate portions of the NTS in vagotomized as well as ganglionectomized rats. However, only the ganglionectomy resulted in the degeneration of medullary nerve fibers. These results suggest that the changes in ChAT activity in the NTS are independent of neuronal degeneration and may be due to transynaptic modulation of ChAT activity by afferent vagal impulses. The presence of ChAT in the sensory nodose projection to the NTS, however, cannot be ruled out.
研究了结状神经节切除术或切断传入迷走神经的外周分支对孤束核（NTS）中胆碱乙酰转移酶（ChAT）活性的影响。在迷走神经切断和神经节切除的大鼠中，NTS经显微解剖的尾侧和中间部分的ChAT活性降低。然而，只有神经节切除术导致延髓神经纤维变性。这些结果表明，NTS中ChAT活性的变化与神经元变性无关，可能是由于迷走神经传入冲动对ChAT活性的跨突触调节所致。然而，不能排除在向NTS的感觉结状投射中存在ChAT。
