禁食、去甲肾上腺素和葡萄糖耐量试验对甲状腺功能减退猪游离脂肪酸和血糖的影响。

Effects of fasting, noradrenaline and glucose tolerance test on free fatty acids and blood glucose in thyroid-deficient pigs.

Macari M, Baraldi S M

Comp Biochem Physiol B. 1983;74(4):743-7. doi: 10.1016/0305-0491(83)90137-2.

Abstract

This experiment was carried out to study the effects of thyroidectomy or treatment with an anti-thyroid drug (Methimazole) on the lipolytic and glycogenolytic responses to fasting, noradrenaline and glucose tolerance test in young growing pigs. 2. Male and female crossbred pigs weighing 15-30 kg were used. 3. Fasting caused a slight hypoglycemic response but without statistical differences between euthyroid and thyroid-deficient animals. 4. Free-fatty acids mobilization was significantly different between euthyroid and thyroid-deficient pigs and, the lipolytic effect of NA was lower in thyroidectomized animals than in treated or euthyroid pigs. 5. Glucose tolerance test was not different among the groups. However, FFA mobilization during the GTT was significantly different. 6. The results suggest that the interaction between catecholamines-thyroid hormones play an important role in the FFA mobilization in vivo.

摘要

本实验旨在研究甲状腺切除术或使用抗甲状腺药物（甲巯咪唑）对幼龄生长猪禁食、去甲肾上腺素和葡萄糖耐量试验的脂解和糖原分解反应的影响。2. 使用体重为15 - 30千克的雄性和雌性杂交猪。3. 禁食引起轻微的低血糖反应，但甲状腺功能正常和甲状腺功能减退的动物之间无统计学差异。4. 甲状腺功能正常和甲状腺功能减退的猪之间游离脂肪酸动员存在显著差异，甲状腺切除动物中去甲肾上腺素的脂解作用低于经治疗或甲状腺功能正常的猪。5. 各组之间葡萄糖耐量试验无差异。然而，葡萄糖耐量试验期间游离脂肪酸动员存在显著差异。6. 结果表明，儿茶酚胺 - 甲状腺激素之间的相互作用在体内游离脂肪酸动员中起重要作用。