Nandi J, Wright M V, Fromm D, Ray T K
Dig Dis Sci. 1983 Jun;28(6):513-7. doi: 10.1007/BF01308153.
Administration of spermine by oral route inhibits the histamine-stimulated gastric acid secretion in pylorous ligated rats. The extent of both the acid and volume of secretion is dependent on the dose of spermine. The polyamine is completely ineffective when injected by the intravenous route. A single oral dose of spermine suppresses acid secretion for at least 6 hr. An inverse relationship between the efficacy of oral spermine and age of the animals was observed. These data suggest a therapeutic potential for the naturally occurring polyamine compounds.
经口给予精胺可抑制幽门结扎大鼠中组胺刺激的胃酸分泌。酸分泌量和分泌体积均取决于精胺的剂量。经静脉注射时，这种多胺完全无效。单次口服精胺可抑制胃酸分泌至少6小时。观察到口服精胺的疗效与动物年龄之间呈负相关。这些数据表明天然存在的多胺化合物具有治疗潜力。
