van der Valk P G, Nater J P, Bleumink E
Derm Beruf Umwelt. 1983;31(2):58-60.
The influence of a number of liquid soaps and detergents on the barrier function of the human skin was investigated by means of skin vapour loss (S.V.L.) measurements. Five liquid cleansers for body use and two liquid dish-cleansers were assayed on the volar side of the forearm. The measurements were performed on 20 healthy volunteers before and after the application of 1 ml of 2 vol.% solution. Five testpersons had to be excluded from the group because of theoretical reasons. The effect on the skin by the applied soaps and detergents was expressed in the average increase of S.V.L. X C. A considerable intra- as well as inter-subject variation of S.V.L. after the application of the test substances could be noted. Each person showed his own pattern of susceptibility. Skin reactions to soaps and detergents as measured by S.V.L. depend not only on the nature of the tested substances but also differ considerably from one person to another. The osmolarity of a test solution may play a role of importance in the irritant effects of soaps and detergents.
通过测量皮肤水分流失（S.V.L.），研究了多种液体肥皂和洗涤剂对人体皮肤屏障功能的影响。在前臂掌侧对五种身体用液体清洁剂和两种液体餐具清洁剂进行了检测。在涂抹1毫升2体积%的溶液前后，对20名健康志愿者进行了测量。由于理论原因，五名测试对象不得不被排除在该组之外。所使用的肥皂和洗涤剂对皮肤的影响通过S.V.L.×C的平均增加来表示。在涂抹测试物质后，可以注意到S.V.L.在个体内以及个体间存在相当大的差异。每个人都表现出自己的易感性模式。通过S.V.L.测量的皮肤对肥皂和洗涤剂的反应不仅取决于测试物质的性质，而且人与人之间也有很大差异。测试溶液的渗透压可能在肥皂和洗涤剂的刺激作用中起重要作用。
