Lightman S, Forsling M, Todd K
Endocrinology. 1983 Jul;113(1):77-80. doi: 10.1210/endo-113-1-77.
Lesions of the circumventricular organs were produced by administration of monosodium-L-glutamate to neonatal rats. At 16 weeks of age these rats were given different stimuli to vasopressin release. In control rats, morphine (50 micrograms) injected into the third ventricle resulted in a rapid increase in plasma vasopressin concentrations at 10 min, followed by a reduction at 20 min. The circumventricular organ-lesioned rats, however, showed a pronounced fall in vasopressin secretion both at 10 and 20 min after 50 micrograms morphine. A similar abolition of the morphine-elicited rise in plasma vasopressin could also be achieved by the iv infusion of small doses of dopamine in normal rats. Hypoxic stimuli, which result in a marked rise in vasopressin in normal rats, failed to elicit any increase in circumventricular organ-lesioned animals. Vasopressin release after stimulation with 9% saline, however, was augmented in the lesioned animals. These results suggest that circumventricular organs have an important role in controlling neurohypophyseal secretion and that they differentially control different stimuli to vasopressin release via dopaminergic and opiate pathways.
通过给新生大鼠注射L-谷氨酸单钠来造成室周器官损伤。在这些大鼠16周龄时，给予它们不同的刺激以释放抗利尿激素。在对照大鼠中，向第三脑室注射吗啡（50微克）会导致10分钟时血浆抗利尿激素浓度迅速升高，随后在20分钟时降低。然而，室周器官损伤的大鼠在注射50微克吗啡后10分钟和20分钟时抗利尿激素分泌均显著下降。在正常大鼠中静脉输注小剂量多巴胺也能类似地消除吗啡引起的血浆抗利尿激素升高。低氧刺激在正常大鼠中会导致抗利尿激素显著升高，但在室周器官损伤的动物中未能引起任何升高。然而，用9%盐水刺激后，损伤动物的抗利尿激素释放增加。这些结果表明，室周器官在控制神经垂体分泌中起重要作用，并且它们通过多巴胺能和阿片途径对不同的抗利尿激素释放刺激进行差异控制。
