Wells T, Forsling M L
Department of Obstetrics and Gynaecology, UMDS, London, U.K.
J Physiol Pharmacol. 1992 Mar;43(1):59-64.
The influence of aminergic pathways on basal and stimulated vasopressin (AVP) release was studied in conscious rats, the stimulus for hormone release being an intracerebroventricular (ICV) injection of 5 microliters 0.85M sodium chloride. The animals were treated with either phenoxybenzamine, propranolol or haloperidol prior to administration of the central hypertonic stimulus. Phenoxybenzamine elevated basal plasma vasopressin concentrations, while propranolol and haloperidol had no effect. The secretion of AVP in response to the hypertonic stimulus was potentiated by phenoxybenzamine and haloperidol, but the effect of propranolol was equivocal. The antagonists had no effect on basal arterial pressure at the time of hypertonic saline administration or the pressor response to ICV sodium chloride.
在清醒大鼠中研究了胺能通路对基础和刺激状态下血管加压素（AVP）释放的影响，激素释放的刺激因素是脑室内（ICV）注射5微升0.85M氯化钠。在给予中枢高渗刺激之前，动物分别接受苯氧苄胺、普萘洛尔或氟哌啶醇处理。苯氧苄胺可提高基础血浆血管加压素浓度，而普萘洛尔和氟哌啶醇则无此作用。苯氧苄胺和氟哌啶醇可增强AVP对高渗刺激的分泌反应，但普萘洛尔的作用不明确。这些拮抗剂在给予高渗盐水时对基础动脉压或对ICV氯化钠的升压反应均无影响。
