Messing R B, Sparber S B
Eur J Pharmacol. 1983 Apr 22;89(1-2):43-51. doi: 10.1016/0014-2999(83)90606-4.
The effects of a vasopressin analog (DGAVP) with minimal endocrinological activity, were assayed on acquisition and extinction of a discrete trial, food reinforced, autoshaped lever touch response. Magazine-trained rats, maintained at 80-85% of free-feeding body weights, were injected s.c. with saline, 5 or 10 micrograms/kg of DGAVP 1 h before each of two sessions in which they learned to touch a retractable lever, presented on a 45 s random interval (RI 45) schedule. Retracted lever contacts (nose-pokes) and unconditioned rearing activity were simultaneously monitored. After acquisition of the extended lever touch response, rats were reassigned to treatment groups, and again injected with saline, 5 or 10 micrograms/kg of DGAVP 1 h before each of two extinction sessions. DGAVP facilitated acquisition (5 micrograms/kg) and slowed extinction (5 and 10 micrograms/kg) of conditioned behavior, while having no effects on the other behaviors, thus demonstrating the specificity of the effect of a vasopressin-like compound on both tasks (enhanced acquisition and retarded extinction) used to study learning.
对一种内分泌活性极小的血管加压素类似物（去甘氨酸 - 精氨酸血管加压素，DGAVP），就离散试验中习得和消退情况进行了测定，该试验为食物强化的自动形成的杠杆触碰反应。对经过食槽训练的大鼠，使其体重维持在自由进食体重的80 - 85%，在两个训练阶段的每一个阶段前1小时，分别皮下注射生理盐水、5或10微克/千克的DGAVP，在这两个阶段中，大鼠要学会触碰一个可伸缩杠杆，杠杆按45秒随机间隔（RI 45）时间表呈现。同时监测缩回杠杆的接触（鼻触）和非条件性竖毛活动。在习得延长的杠杆触碰反应后，将大鼠重新分配到各治疗组，并在两个消退阶段的每一个阶段前1小时，再次分别注射生理盐水、5或10微克/千克的DGAVP。DGAVP促进了条件性行为的习得（5微克/千克）并减缓了其消退（5和10微克/千克），而对其他行为没有影响，从而证明了一种血管加压素样化合物对用于研究学习的两项任务（增强习得和延缓消退）的作用具有特异性。
