饲养层细胞条件培养基抑制胚胎癌细胞培养物的分化。
Medium conditioned by feeder cells inhibits the differentiation of embryonal carcinoma cultures.
作者信息
Smith T A, Hooper M L
出版信息
Exp Cell Res. 1983 May;145(2):458-62. doi: 10.1016/0014-4827(83)90025-3.
PMID:6861901
Abstract
Non-dividing STO mouse fibroblasts have been used for some time as feeder cells for maintaining certain embryonal carcinoma cells in an undifferentiated state. We report here that medium conditioned by these feeders can inhibit embryonal carcinoma (ec) cell differentiation induced either by removal from feeders, or, in the case of cells not normally requiring a feeder layer, by retinoic acid treatment.
摘要
非分裂的STO小鼠成纤维细胞已被用作饲养细胞一段时间，用于将某些胚胎癌细胞维持在未分化状态。我们在此报告，这些饲养细胞条件化的培养基可以抑制胚胎癌细胞（ec）的分化，这种分化是由从饲养细胞中移除诱导的，或者，对于通常不需要饲养层的细胞，是由视黄酸处理诱导的。
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