Saint-Cyr J A, Woodward D J
Exp Brain Res. 1980;40(1):13-22. doi: 10.1007/BF00236658.
The effects of electrical stimulation of the fornix, snout, and limbs on the activity of electrophysiologically identified Purkinje cells were investigated. Extracellularly recorded responses were analyzed according to: latency; mode of termination as mossy or climbing fibers; and, whether excitatory or inhibitory responses were evoked. The positions of responsive cells were transposed onto a planar representation of the Purkinje cell layer of the rat cerebellum derived from a series of sagittal sections. Fornix responsive cells were found in the vermis of lobules IV, V, VI, and VII as well as in the paravermal regions of lobules II--VIIb. In addition, some evidence was obtained for a projection to lobulus simplex. Snout stimulation activated cells mainly in the vermis of lobule VI and also in adjacent lobules III, IV, V, and VIIa. A few responsive cells were also found in the paravermal regions of lobules V, VI, and VIIa and in the lateral portion of lobulus simplex. Forelimb responsive cells were located mainly in the vermis of lobules IV--VIa and in the paravermal protion of lobules III--VII. The few hindlimb cells encountered were located in the vermis and paravermis of lobules II--IV. The topographical overlap of the fornix projection with areas in receipt of forelimb, snout, neck, and auditory-visual teleceptor input suggests that the fornix-mediated information may modulate cerebellar circuits involved in postural adjustment, general orienting, and exploratory motor behavior.
研究了电刺激穹窿、口鼻部和肢体对经电生理鉴定的浦肯野细胞活性的影响。根据以下方面分析细胞外记录的反应：潜伏期；终止方式（苔藓纤维或攀缘纤维）；以及诱发的反应是兴奋性还是抑制性。将反应性细胞的位置转换到从一系列矢状切片得出的大鼠小脑浦肯野细胞层的平面表示上。在小叶IV、V、VI和VII的蚓部以及小叶II-VIIb的旁蚓区域发现了对穹窿有反应的细胞。此外，还获得了一些证据表明存在向单小叶的投射。刺激口鼻部主要激活小叶VI蚓部的细胞，也激活相邻的小叶III、IV、V和VIIa的细胞。在小叶V、VI和VIIa的旁蚓区域以及单小叶的外侧部分也发现了一些反应性细胞。前肢反应性细胞主要位于小叶IV-VIa的蚓部以及小叶III-VII的旁蚓部分。遇到的少数后肢细胞位于小叶II-IV的蚓部和旁蚓部。穹窿投射与接受前肢、口鼻部、颈部和视听远距感受器输入的区域在地形上的重叠表明，穹窿介导的信息可能调节参与姿势调整、一般定向和探索性运动行为的小脑回路。
