Belykh A G
Farmakol Toksikol. 1983 May-Jun;46(3):105-8.
In the first approximation the process of distribution of the radiographic contrast agent bilignost may be formalized with the aid of a linear two-compartmental model, while generally, with the aid of a non-linear many-compartmental perfusion model of the pharmacokinetics. Pharmacokinetic analysis of experimental data has shown that the decreased content of bilignost in the liver during acute carbon tetrachloride poisoning is largely determined by the impairment of radiographic contrast agent absorption by the liver.
在初步近似中，双碘葡胺造影剂的分布过程可以借助线性二室模型进行形式化描述，而一般来说，则需借助药代动力学的非线性多室灌注模型。对实验数据的药代动力学分析表明，急性四氯化碳中毒期间肝脏中双碘葡胺含量的降低很大程度上是由肝脏对造影剂吸收的损害所决定的。
