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Synthesis, acute toxicity and chemotherapeutic anti-cancer activities of a new tripeptidic mustard.

作者信息

De Barbieri A, Dall'Asta L, Comini A, Springolo V, Mosconi P, Coppi G

出版信息

Farmaco Sci. 1983 Apr;38(4):205-18.

PMID:6861998
Abstract

A new antitumor agent having the chemical composition of 3-(p-fluorophenyl)-Lalanyl-3-[m-bis-(2-chloroethyl)aminophenyl]-L- alanyl-L-methionine ethyl ester hydrochloride (PTT 119) was synthetized. It fundamental toxicological data in mice and rats were assessed; its antitumor activity was investigated by establishing in mice, inoculated with L 1210 leukemia or in AKR mice with spontaneous leukemia of viral origin, a significant increase in Mean Survival Time as well as a percent increase of Increased Life Span and of the number of survivors.

摘要

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Synthesis, acute toxicity and chemotherapeutic anti-cancer activities of a new tripeptidic mustard.
Farmaco Sci. 1983 Apr;38(4):205-18.
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[Research on compounds with antiblastic activity. XLI. Synthesis of new nitrogen mustards correlated with N,N-bis-(beta-chlorethyl) aniline].
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Phase II study of a new alkylating agent (PTT-119) in resistant-relapsed non-Hodgkin's lymphomas.新型烷化剂（PTT-119）用于难治性复发非霍奇金淋巴瘤的II期研究
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