Tsunawaki S, Ikenami M, Mizuno D, Yamazaki M
Gan. 1983 Apr;74(2):265-72.
The mechanisms of tumor lysis by polymorphonuclear leukocytes (PMNs) were investigated. In antibody-dependent PMN-mediated cytolysis (ADPC), sensitized tumor cells were specifically lysed via Fc receptors on PMNs. On the other hand, lectin-dependent PMN-mediated cytolysis (LDPC) caused nonspecific lysis of several murine tumors after recognition of carbohydrate moieties on the cell membrane of both PMNs and tumor cells. Both ADPC and LDPC depended on glycolysis, and cytotoxicity was mediated by reactive oxygen species; LDPC was dependent on superoxide and ADPC on the myeloperoxidase system. The participation of reactive oxygen species in PMN cytotoxicity was also demonstrated by pharmacological triggering with phorbol myristate acetate. These results indicate that reactive oxygen species have an important role In tumor killing by PMNs and that ADPC and LDPC have partly different cytolytic processes as well as different recognition steps.
对多形核白细胞（PMN）介导肿瘤溶解的机制进行了研究。在抗体依赖的PMN介导的细胞溶解（ADPC）中，致敏肿瘤细胞通过PMN上的Fc受体被特异性溶解。另一方面，凝集素依赖的PMN介导的细胞溶解（LDPC）在识别PMN和肿瘤细胞膜上的碳水化合物部分后，会导致几种小鼠肿瘤的非特异性溶解。ADPC和LDPC都依赖糖酵解，细胞毒性由活性氧介导；LDPC依赖超氧化物，ADPC依赖髓过氧化物酶系统。佛波酯肉豆蔻酸酯乙酸盐的药理学触发也证明了活性氧在PMN细胞毒性中的参与。这些结果表明，活性氧在PMN杀伤肿瘤中起重要作用，并且ADPC和LDPC具有部分不同的细胞溶解过程以及不同的识别步骤。
