Sigurdsson K, Alm P, Gullberg B
Gynecol Oncol. 1983 Jun;15(3):370-80. doi: 10.1016/0090-8258(83)90055-0.
In a study of 494 patients with ovarian carcinoma all known factors that eventually influence prognosis were tested both separately and comparatively in a multivariate statistical analysis, using survival as the dependent variable. It was found that the histologic grade and the size of the residual tumor after surgery are the most important factors influencing survival. The histologic type affected prognosis only in Stage III patients with large residual tumors. The stage of tumor progression had prognostic value, although Stage IIa was found to have the same survival rate as Stage I of this disease. The state of the tumor capsules in Stage I had no prognostic effect. Ascites only affected survival in Stage III patients who had small or no residual tumor after surgery. Age was found to influence survival only in Stage III patients with small residual tumors, or no residual tumor, and in advanced Stage II cases. Continued chemotherapy seems to be of benefit in Stage III patients with small or no residual tumors following surgery.
在一项针对494例卵巢癌患者的研究中，所有最终影响预后的已知因素都在多变量统计分析中分别进行了测试，并进行了比较，将生存率作为因变量。结果发现，组织学分级和手术后残留肿瘤的大小是影响生存的最重要因素。组织学类型仅在有大残留肿瘤的III期患者中影响预后。肿瘤进展阶段具有预后价值，尽管发现IIa期与该疾病的I期生存率相同。I期肿瘤包膜状态无预后影响。腹水仅影响术后残留肿瘤小或无残留肿瘤的III期患者的生存。发现年龄仅在残留肿瘤小或无残留肿瘤的III期患者以及晚期II期病例中影响生存。对于术后残留肿瘤小或无残留肿瘤的III期患者，持续化疗似乎有益。
